Best of luck on your next FET! (I had these done at a private lab since my nurse wouldn't let me come in early) My last donor embryo cycle was also a chemical pregnancy but no PGS was done. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. Dogpark in reply to Mogwai_2 3 years ago. It kind of makes me wonder what they get out of their alternative recommendations. They havent discontinued my medication they want me to continue until further instructions. At this point I am waiting to start my 5th miscarriage. As that was the only PGS normal embryo we had, I ended up having to do another egg retrieval. I haven't done the transfer yet due to various reasons, and even though nothing is guaranteed, I like going into it knowing that I have a better chance because it is a normal embryo. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. I remember you from another post I made about only having 2 eggs fertilized you were so kind to share your story. Looking for anyone who has had recurrent chemical pregnancies and then found success. PGS enhances the success of IVF but not in all cases; the success rates vary by age. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. My result came with a high risk, 1 in 11 chances of the baby having Down Syndrome. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. How fast embryos grow has an impact on success rates for untested embryos. Chemical pregnancies occur so early that many people who miscarry don't realize it. One clinic determined IVF with PGS success rates to have a 10% higher pregnancy rate. You got this! I agree with the others that you should push for some sort of testing or SOMETHING to investigate before trying again (if you haven't already). Objective: To determine whether undetected aneuploidy contributes to pregnancy loss after transfer of euploid embryos that have undergone array comparative genomic hybridization (aCGH). Of course the quality of the embryo is everything but there is significantly more uterine prep with a frozen transfer and I think it helped. This was our first trial. Check here for the full glossary (please excuse the repeated terms!). Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid Hello, A chemical pregnancy is an early pregnancy loss before ultrasounds can detect a fetus. It worked and now I'm 24 weeks pregnant with twins! Zhao et al. It was an incredibly long and intense process but looking back I did not have time on my side for my eggs so it was the right decision for us. After the first, we did the era and added the endo scratch. hang in there. A few rounds of heavy- duty antibiotics cleared it up. Very frustrating to have an inconclusive. That sounds a lot like my dr. Its basically an assembly line in there. thank you for sharing! Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. My doctor told me you can have an infection in the uterus and have no symptoms. Autoimmune Testing? Women above 35 seem to benefit the most with PGS . Last year I got pregnant from an IUI and miscarried at 8 weeks. 2005-2023Everyday Health, Inc., a Ziff Davis company. We were told not to worry and try again after a month, and in March I found I was pregnant again but this turned out to be a chemical pregnancy. We have one (and only one) 4bb PGS normal embryo. (2017)had similar results to above (aCGH, women <35): Capalbo et al. Last January we found out we were pregnant but had a miscarriage at 7 weeks. My first FET failed and it was devastating. Im hoping to do another transfer in January. Good luck and wishing baby dust your way soon! Don't lose hope! They found that: If you want to read my summary of this paper, check here. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). Trying naturally, assisted, etc. One thing Ive definitely learned from all of this is to trust my gut instinct. My current doctor reviewed my history and suggested an endometrial biopsy for endometritis (different from endometriosis). , Ive done embryo glue every transfer but no luck unfortunately :(. 1) Has anyone else had the immune suppressing protocol NOT work, and then gone on to have it work? You guys have given me so much support and reassurance that I'm not alone in this ordeal. (The embryo split!) If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. Best of luck! A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. I go for my next Beta tomorrow. Please whitelist our site to get all the best deals and offers from our partners. Or they did but they were all aneuploid? I guess I'm facing wasting the investments of stimulation vs potentially wasting the investments in proceeding but also getting more information that might help with future cycles. With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. I think its valuable information because many people dont realize the chances of not getting blasts/eligible blasts for biopsy. If you did PGS after multiple miscarriages and failed attempts how many did you transfer? (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. Im assuming as the levels drop theyll wean me off. My second Beta I dropped to 59. I cannot even imagine how it mustve been to go through all of that but Im happy to hear you finally got your miracle!!! For <37, this was about 5, for 37-40 about 4, and for >40 about 3 (so older women tend to produce fewerblasts). If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. (2017)found a reduction in embryo survival (from 98% to 93%) and a reduction inlive birth rate(50% to 27%). PGS testing (aka PGT-A) is a technique to help choose the best embryo for an embryo transfer. My questions is only 28% of our blastocysts passed pgs testing which is quite low from what is predicted for those under 35. (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). Create an account or log in to participate. Check out mycomplete guide to embryo grading and success ratesto learn more about embryo development, grading and success rates. Yes, and I believe it was due to doctor negligence. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Disclaimer: Any studies presented here may be contradicted by other studies. ALL THREE DID!!! Interestingly enough my protocol remained the same between my chemical FET and the successful one. Or adding an immune protocol if you didnt with this FET. Hello. I just wish we had more answers so we can prepare for the next . I"ve not had a chance to actually talk with my RE yet, hopefully I will tomorrow after I go back for monitoring. Segmental aneuploids: the main source for PGT-A false positives? And since then Ive had medical issues that havent allowed me to try again until last month. Good luck to you on this journey and I hope round 2 is successful for you!! Well start with euploids, then mosaics, and end with fully aneuploid embryos. But it seems like the majority of twin pregnancies result in healthy babies. My first, was a success. Sending you positive thoughts . Currently 8 weeks. I cried the whole way home. thats a great suggestion! I feel like most times the protocol for autoimmune issues is the same. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. Most of the patients in the studies were <35. Dear T3BK, thank you so much for your reply! The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Aww happy your second round worked! You cant compare the per retrieval and per transfer stats against each other directly. Success rates for graded euploids are given here https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates. Segmental mosaics or single chromosome mosaics tend to perform better than multiple chromosome abnormalities which can approach 50% miscarriage rates. They biopsied those 2 embryos and send off the cells for PGS testing. Kelly. I hope the ERA works too. If it's any consolation, we also did acupuncture with the failed FET, but not the one that worked. Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done. Well also look at the chances of getting a euploid based on age, the impact of embryo grade and the day it was frozen (Day 5, 6 or 7), and how rebiopsies or thaw and biopsies fare for success rates. Consult with your doctor before making any treatment changes. Obviously, when we look at transfer rates with PGS tested embryos, we are not including all the women who didnt have anything to transfer. Mosaics are often transferred after euploid embryos have been exhausted, although there is evidence that low level mosaic transfers are comparable to euploid transfers (see here for a review). We got to see and hear the heartbeat yesterday. To do PGT-A, a sample of cells (a biopsy) is taken from the embryo and is submitted for DNA testing in a separate lab. Congratulations on your pregnancy xxx Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Thats what i needed to hear. Pregnancy rates will be higher because not everyone will have a live birth (some miscarry). Whitney et al. And Im so sorry about your first FET. Learn more about, Learn About What to Expect's Pregnancy & Baby App. Once they see it on an U/S, I think it becomes a clinical pregnancy. Chemical pregnancy is an early miscarriage. It worked and now Im 24 weeks pregnant with twins! And congrats on your little girl! Thanks again! My dr never mentioned anything regarding epigenetic issues. It sucks cause I only have one shot left at this and Im already against odds cause its a day 7 embryo , So RE doesnt think i need ERA because I did get pregnant. 2 - IUIs both chemical Thank you Its so hard when youre paying yet your doctor doesnt think its needed. Use of this site is subject to our terms of use and privacy policy. For women who have it, REs may suggest prednisone and lovenox after transfer. Nov 2016-IVF #2 16 eggs -> 3 PGS-normal embryos Jan 2017-single FET #2: BFN . Im sure that data exists especially since thats how things used to be done back in the day. I don't know how many more cycles I can do as my emotional reserve is running low. All genetically untested embryos. Generally, Day 5 embryos perform better than Day 7 embryos. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Have you ever had an endometrial biopsy to look for infection? Is it because they were early blastocysts? Just thought Id throw this test out there though! Then a frozen cycle BFN. There is much better chance of IVF success with PGS testing in women who were over the age of 35. It would be a miracle to have a similar experience as yours , I know you said age is a factor, but you could always take a month or two off for your mental health and then re-assess. I was put on the Schoyer protocol for stimulation. Check here for the full. END MENTS. Wishing you lots of luck. We PGS tested the whole batch of embryos at once at the end of all the retrievals. Trade-offs of PGT-A (or PGS) Im going to try and run it by her again to see what she thinks. As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). Existing data show that the live birth rate is between 60-80% when a single frozen embryo is transferred in a second cycle. I am 41 years old. I dont see myself spending a fortune on acupuncture again. Hopefully an ERA can shed some light on it! Im so sorry to hear about your losses but so happy with your current miracle. A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . Jun 13, 2021 2:33 PM It is looking like we will have a second consecutive blighted ovum with a PGS normal embryo. How about a mosaic? So they were both frozen on Day 6? Im still u sure if this will go to term, but getting a 2nd opinion from a specialist in RPL sure has made a difference. PGT-A meta-analysis finds live birth rates only improve with older patients, Complete Guide to Embryo Grading and Success Rates, PGS testing doesnt improve success in good prognosis patients, No difference in euploid and mosaic embryo transfers: a clinical trial, Embryo biopsy of small embryos dramatically reduces IVF success rates, 144 abnormal (aneuploid/mosaic) embryos and their outcomes, Overall there was no statistical difference in miscarriage rates (9.9% in the, For women <35 years old, there was no statistical difference (11.2% for. The chart below, based on information published in Reproductive Biomedicine Online, in 2016, shows:. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). great to know! frustration and tears were worth it. My RE had said shes usually very cautious when it comes to sending embryos out for PGS testing only because the process can sometimes compromise the embryo itself. A pregnancy that doesn't even make it to the 6 week scan where they can usually see the fetus on an ultrasound. More studies need to be done. After my negative, we did ERA and had a hysteroscopy to correct a small septum. So all the aneuploid embryos that were transferred either didnt implant, or miscarried. For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. If your window is off I would think that could cause chemical pregnancies because the embryo would have a hard time implanting. Best of luck to you. I am so so sorry. Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. Its good you will request the endomitritis biopsy. Thank you TXtoCA, Im definitely planning to make changes. That said, Im still glad that I pursued additional testing and second opinions just in case. If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. Some of the reasons quoted werent even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, theres a margin of error with the testing itself, pgs doesnt tell us everything about an embryo, etc. According to the authors, the >35 group analysis should be interpreted with caution as the sample size was small. For more background info, check out my post onPGS Testing. I'm so sorry for your loss. Definitely heartbroken but trying to look forward. By 40 theres about a 1 in 4 chance of not getting a euploid and by 43 this doubles to half. Endomitritis is basically an inflammation in the uterus that makes it inhospitable for an embryo to implant or grow. Are you sure you want to block this member? I had been on birth control since I was 18 and had no idea what to expect when I came off it. When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. Did your doctor have your SO go through the rounds of antibiotics as well? Reply Share React operationpepper Dec 22, 2015 3:42 PM Viotti et al. I know that every cycle + embryo is different, but it's so hard to not compare cycles. PGS Normal FET Results in Chemical Pregnancy *with* autoimmune protocol, Need some Love!!! I have one more embryo remaining. Most assume theyll get the stats that are reported per transfer without knowing if theyll get eligible blasts or not. However, these differences were not found in women older than 30 years. Please can you offer a perspective? I will talk to my dr about all of the above and hopefully i can finally get some answers :) My dr keeps pinning it on my lining but it doesnt make sense to me since Ive been over 8mm with a triple line pattern each chemical. Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. I had a chemical pregnancy last November after a fresh transfer. Alternatively you can check out my websites tag for mosaic embryos here. 2005-2023Everyday Health, Inc., a Ziff Davis company. The protocol was exactly the same as with the chemical pregnancy with addition of baby aspirin. Hi Mogwai_2 Theses are rates for PGS normal embryos. Preliminary studies examine the rebiopsy and transfer of chaotic embryos by PGT-A. Ill have to ask my RE for options. Seems to work for many, many women. Find advice, support and good company (and some stuff just for fun). The embryo biopsy can be utilized to perform preimplantation genetic screening or PGS. Good luck and feel free to PM me. Im assuming you had no issues shipping yours? Did you carry to full term? The majority of these studies used double embryo transfers, either when transferring euploid embryos, in the control untested groups, or both. But then the 3 mature eggs I had all fertilized, all made it to blast, all tested normal, and now one of them is my 15 month old daughter. END MENTS We really expected to find success with our first pgs transfer even though our company and RE only quoted 60% odds per embryo transferits a good but tough reminder that its not expected to always work. We put both in and im currently 8weeks pregnant. The good thing is she did not see any scar tissue during the biopsy, and the inflammation had completely cleared up. Note that once you confirm, this action cannot be undone. Use of this site is subject to our terms of use and privacy policy. We have not done a hysteroscopy but will ask my dr if we can do one to check and at least rule that out. Please whitelist our site to get all the best deals and offers from our partners. HCG was 24 Friday and yesterday went down to 16. Are there recent numbers for this comparison? Hi, i didnt have chemicals, I had bfn for my first two transfers. 35 years old Your post will be hidden and deleted by moderators. MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. . At this point I am wondering the following: The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband.
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